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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Shogaol, Gemcitabine
Phytochemical Name Shogaol (PubChem CID: 5281794 )
Anticancer drug Name Gemcitabine (PubChem CID: 60750 )
Structure of
Phytochemical		 2D-img
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2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 870
Ref_1
Pair Name Shogaol, Gemcitabine
Disease Info [ICD-11: 2C10.0] Pancreatic ductal adenocarcinoma Investigative
Gene Regulation Down-regulation Expression BIRC5 hsa332
Up-regulation Cleavage CASP3 hsa836
Down-regulation Expression CCND1 hsa595
Down-regulation Expression COX2 hsa4513
Down-regulation Activity NFKB1 hsa4790
Up-regulation Cleavage PARP1 hsa142
Down-regulation Phosphorylation RELA hsa5970
Down-regulation Activity TLR4 hsa7099
Down-regulation Expression XIAP hsa331
In Vitro Model PANC-1 Pancreatic ductal adenocarcinoma Homo sapiens (Human) CVCL_0480
BxPC-3 Pancreatic ductal adenocarcinoma Homo sapiens (Human) CVCL_0186
In Vivo Model Male BALB/c immunodeficient nude mice were injected with PANC-1 cells (1×10⁷) with matrigel (100 uL) to the right flank of each mice.
Result Our results suggest that 6-shogaol can inhibit the growth of human pancreatic tumors and sensitize them to gemcitabine by suppressing of TLR4/NF-κB-mediated inflammatory pathways linked to tumorigenesis.
03. Reference
No. Title Href
1 Antitumor activity of gemcitabine can be potentiated in pancreatic cancer through modulation of TLR4/NF-κB signaling by 6-shogaol. AAPS J. 2014 Mar;16(2):246-57. doi: 10.1208/s12248-013-9558-3. Click
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